The Mampruli language of Ghana is spoken by over 326,000, most of whom reside in the Northern region: east and west of Gambaga; Upper East region: scattered border areas north of the White Volta river, between Pwalagu and Zongoiri.

The language is classified as: Niger-Congo, Atlantic-Congo, Volta-Congo, North, Gur, Central, Northern, Oti-Volta, Western, Southeast. The ISO code is [maw]. Alternate names include: Mampelle, Mamprule, Mamprusi, Mamprussi, Manpelle, Ngmamperli, Nmampurli, and Ŋmampəlli. There is one dialect called Eastern Mampruli. There is some lexical similarity with Dagbani [dag] and Farefare [gur] to Mampruli.

Mampruli is the de facto provincial language in the northeast North Region of Ghana. It is a important language used in all domains of community life. The Konni language group also speak some Mampruli.